Protein name:
WW domain-containing oxidoreductase ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with TP53, TP73/p73 and MAPK8. Interacts with MAPT/TAU. Forms a ternary complex with TP53 and MDM2 and interacts with ERBB4, LITAF and WBP1. May interact with COTE1 and SCOTIN (By similarity). Interacts with HYAL2 and RUNX2. Interacts with TNK2.
Function:
Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm (By similarity). May also play a role in tumor necrosis factor (TNF)-mediated cell death. Required for normal bone development.
Subcellular Location:
Cytoplasm
Nucleus
Mitochondrion
Partially localizes to the mitochondria (By similarity). Translocates to the nucleus in response to TGFB1 (By similarity). Translocates to the nucleus upon genotoxic stress or TNF stimulation.
Protein Attributes:
50:
MAALRYAGLD | DTDSEDELPP | GWEERTTKDG | WVYYANHTEE | KTQWEHPKTG |
100:
KRKRVAGDLP | YGWEQETDEN | GQVFFVDHIN | KRTTYLDPRL | AFTVDDNPTK |
150:
PTTRQRYDGS | TTAMEILQGR | DFTGKVVLVT | GANSGIGFET | AKSFALHGAH |
200:
VILACRNLSR | ASEAVSRILE | EWHKAKVEAM | TLDLAVLRSV | QHFAEAFKAK |
250:
NVSLHVLVCN | AGTFALPWGL | TKDGLETTFQ | VNHLGHFYLV | QLLQDVLCRS |
300:
SPARVIVVSS | ESHRFTDIND | SSGKLDLSRL | SPPRSDYWAM | LAYNRSKLCN |
350:
ILFSNELHRR | LSPRGVTSNA | VHPGNMMYSA | IHRNSWVYKL | LFTLARPFTK |
400:
SMQQGAATTV | YCAVAPELEG | LGGMYFNNCC | RCLPSEEAQS | EETARALWEL |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Chicken
Mouse
ELISA Kit for Mouse WW domain-containing oxidoreductase
ELISA Kit for Mouse WW domain-containing oxidoreductase
ELISA Kit for Mouse WW domain-containing oxidoreductase
CLIA Kit for Mouse WW domain-containing oxidoreductase
CLIA Kit for Mouse WW domain-containing oxidoreductase
CLIA Kit for Mouse WW domain-containing oxidoreductase
Polyclonal Antibody for Mouse WW domain-containing oxidoreductase
Polyclonal Antibody for Mouse WW domain-containing oxidoreductase
Polyclonal Antibody for Mouse WW domain-containing oxidoreductase
Monoclonal Antibody for Mouse WW domain-containing oxidoreductase
Monoclonal Antibody for Mouse WW domain-containing oxidoreductase
Monoclonal Antibody for Mouse WW domain-containing oxidoreductase
Protein for Mouse WW domain-containing oxidoreductase
Protein for Mouse WW domain-containing oxidoreductase
Protein for Mouse WW domain-containing oxidoreductase
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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PubMed ]
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Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4)
strain :
C57BL/6J .
tissue :
Cerebellum .
tissue :
Colon .
tissue :
Embryo .
tissue :
Pituitary .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain :
FVB/N .
tissue :
Kidney .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 173-414
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH MAPK8 AND TP53
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Embryonic brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;PHOSPHORYLATION AT TYR-33;SUBCELLULAR LOCATION;INTERACTION WITH HYAL2